1000 ways to be crippled by life

Exhaustion: -4 to all rolls until sleep. Every extra point of exhaustion cumulatively decreases con by 1. Every night of normal sleep restores 1 con.

Dehydration: -4 to all rolls until drinking. After 2 day of not drinking, roll con saves every day against death.

Starvation: After [con] days of not eating, -4 to all rolls until your first substantial meal. After [con]x2 days of not eating, 10 minute rests no longer provide healing. After [con]x3 days of not eating, physical stats drop to 1. After [con]x4 days of not eating, con save every day against death.

Blindness and partial blindness are usually caused by darkness, but can also be caused by excess light. Some examples of partial blindness conditions: 

• You observe the region just beyond your 30 feet of torchlight 
• Your only source of light is a candle 
• Moonlit nights 
• Large amounts of shadows 
• Snowblinding 
• Looking directly into water on a bright day 
• Heavy weather

Partial Blindness: You can see general shapes but only very low levels of detail. Attacking things is hard (-2) and you can’t really make out what you’re even looking at. Time is less of an issue though, detail can still be mostly seen if up very close.

Blindness: Can’t see shit. You get basically no descriptions of a room you crawl through besides the dimensions, sounds, smells, and large objects. 10 minutes of searching gives you the same information you would have initially gotten with vision. Another 10 minutes would be required to learn anything more. Everything takes more time. (-4 to hit if you can sense the creature without sight, almost impossible to attack without information).

Paralysis: Every attack against you hits and crits. Voluntary movement impossible.

Drunk: Increases crit fumble range by 1 for every drink.

Cannibalism: Every time you partake in cannibalism, roll a con save. Once you fail, your body will begin the process of ghoulification. Normal food turns to ash in your mouth; only meat sates the hunger, and only human meat sates it for any significant length of time. 

• Every day without human meat requires a cha save to prevent pursuing the consumption of human meat. Every day without consuming human meat adds a -1 penalty to the save.
• Completing the process of ghoulification requires a steady diet of humans over about a month.
• Exact conditions have not been decided but would be: increased strength, eventual undeath, paralytic claws, ravenous hunger, darkvision, ability to climb walls and ceilings

Awakening: Stay awake for 3-4 weeks and you will Awaken. The PC becomes an NPC unless the player (and the group) consents to acting out explicitly and completely psychotic behaviors.